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3. Rovati LC. Clinical development of glucosamine sulfate as selective drug in osteoarthritis. Rheumatology Europe 1997;26:70.

11. Bassleer C., Reginster JY., Franchimont P. Effect of glucosamine on differentiated human chondrocytes cultivated in clusters. Rev Esp Reumatol 1993; 20 (suppl):96.

New appoaches in OA. Zurich:Litera Rheumatologica 24, EULAR;1999:1520.

8. Baici A, Bradamante P. Interaction between human leukocyte elastase and chondroitin sulfate. Chem Biol Interaction 1984; 51:111.

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13. Reveliere D, Mentz F, MerieBeral H et al. Protective effect of chondroitin 4,6sulfate on apoptpsis of rabbit articular chondrocytes preliminary resultes. In: Mautone G, Tajana E, Rovati S, Vacher D, editors.

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14. McAlindon T, Formica M, LaValley M, Lehmer M, Kabbara K. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internetbased randomized doubleblind controlled trial. Am J Med 2004 Nov 1; 117(9):6439.

1. Uebelhart D, Knussel O, Theiler R. Efficacy and tolerability of oral chondroitinsulfate in painful knee osteoarthritis: a doubleblind, placebocontrolled, multicentre 6month trial. Osteoarthritis Cartilage, 1999;7, Suppl A, abstr 144.

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9. Lippielo L, Grande D. In vitro chondroprotection of glucosamine and chondroitin sulfate in a rabbit model of a OA and demonstration of metabolic synergy on chondrocyte in vitro. Ann Rheum Dis 2000, 59 (Suppl 1):266.

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7. Rovati LC. Clinical efficacy of glucosamine sulfate in osteoarthritis of the spine. Rev Esp Reumatol 1993;20:325.

5. Malaise M, Marcolongo R, Uebelhart D, et al. Efficacy and tolerability of 800 mg oral chondroitin 4,6sulfate in the treatment of knee osteoarthritis: a randomized, doubleblind multicentre study versus placebo. In: Mautone G, Tajana E, Rovati S, Vacher D, editors. New a ppoaches in OA.

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15. Lippielo L., Woodword J., Karpman D. et al. Beneficial effect of cartilage structure modyifing agents tested in chondrocyte and rabbit instability model osteoartrosis. Arthr. Rheum., 1999, suppl.

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12. Sandy JD, Boyer H, Hymer SS et al. Control of chondrocyte aggrecanase by glutamine supply. Transaction of the 44th Annual Meeting of the Orthopedic Research Society; New Orleans, LA; March 1998.

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6. Uebelhart, Thonar E, Delmas P et al. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage 1998; 6 (suppl A): 3946.

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4. Register JY, Rovati L, Deroisy R et al. Glucosamine sulfate slowsdown osteoarthritis progression in postmenopausal women : pooled analysis of two large, independent, randomized, placebocontrolled, doubleblind, prospective 3year trials. Ann Rheum Dis 2002, 61 (Suppl 1):THU0196.

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10. Yaron I, Shirasi R, Judovich R, Yaron M. Chondroitin sulfate inhibits prostaglandin E2 production in synovial cell cultures and reverses IL1 inhibition of cartilage synthesis. Ann Rheum Dis 2000, 59 (Suppl 1):265.

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