DerBosenWolf
, 27 2005 . 16:13 ()
Phenelzine/Nardil
Phenelzine is a MAOI;
DOSING INFORMATION: Recommended oral adult doses of phenelzine are 45 to
75 mg/day; alternatively,
- Onset of activity is noted within 2 weeks, however, maximal effects are
not seen until up to 6 weeks of therapy.
- Phenelzine is well absorbed following oral administration and is
excreted primarily as metabolites in the urine.
- Phenelzine should be used cautiously in combination w/ tricyclic
antidepressants or other MAO inhibitors; foods with a high tyramine
content should be avoided.
- Frequent adverse effects of phenelzine include orthostatic hypotension,
drowsiness, dizziness, mania, agitation, and weight gain.
- anticholinergic agents be avoided whenever possible;
- meperidine should definitely be avoided, whereas fentanyl or morphine
appear to be suitable during Hanesthesia;
- enflurane or isoflurane are preferred over halothane because of reduced
arrhythmogenic potential;
- due to the possibility of hypotension associated with spinal and
epidural anesthesia and the subsequent requirement for
basopressors general anesthesia is preferred.
MAO Inhibitors:
- Isocarboxazid/Marplan
- Tranylcypromine/Parnate
- Phenelzine/Nardil
- can potentiate the depressive effects of narcotics;
- can cause fever and seizures when administered to a patient receiving MAOI;
- the pressor effect of indirectly acting agents such as ephedrine
may be greatly exagerated;
- the traditional recommendations are that MAOI be discontinued 2 weeks
before surgery;
- anticholinergic agents be avoided whenever possible;
- meperidine should definitely be avoided, whereas fentanyl or morphine
appear to be suitable during Hanesthesia;
- enflurane or isoflurane are preferred over halothane because of reduced
arrhythmogenic potential;
- due to the possibility of hypotension associated with spinal and
epidural anesthesia and the subsequent requirement for
basopressors general anesthesia is preferred.
DerBosenWolf
, 27 2005 . 16:13 ()
