Charles Santore ðîäèëñÿ â Ôèëàäåëüôèè â 1935 ãîäó.Çàêîí÷èë Óíèâåðñèòåò èñêóññòâ, ãäå èçó÷àë èëëþñòðàöèþ.
Ñ íà÷àëà øåñòèäåñÿòûõ, åãî ðàáîòû ïîÿâëÿþòñÿ â òàêèõ êðóïíûõ èçäàíèÿõ êàê Redbook, Ladies Home Journal, Esquire, Cosmopolitan, National Geographic.
Èëëþñòðàöèè Charles Santore ÿâëÿþòñÿ ÷àñòüþ ïîñòîÿííîé êîëëåêöèè Brandywine River Museum, Chadds Ford, PA, The Free Library of Philadelphia, New York City’s Museum of Modern Art, The United States Department of the Interior è ìíîãèõ ÷àñòíûõ êîëëåêöèé.
Äâå åãî ðàáîòû ÿâëÿþòñÿ ýêñïîíàòàìè ïåðåäâèæíîé âûñòàâêè îçàãëàâëåííîé "Myth, Magic and Mystery. One Hundred Years of American Children’s Book Illustrations."
Åãî íàãðàäû, ýòî ïðåìèÿ Hamilton King Award from the New York Society of Illustrators, çîëîòàÿ ìåäàëü New York Society of Publication Designers è "Edger" îò Mystery Writers of America. Ñàéò