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Среда, 09 Марта 2011 г. 20:10 (ссылка)
Дмитрий Медведев и Владимир Путин так озабочены преследованием Михаила Ходорковского, что не заметили российскую научную онко-мафию. Дмитрий Медведев и Владимир Путин! Пробудитесь!
Лео Зачарский, Бразильские Исследователи и Ферромагнитная Теория Канцерогенеза.
Leo R. Zacharski, Brazilian Researchers and Ferromagnetic Theory of Cancer.
Brazilian Researchers investigate brilliant ideas of Leo R. Zacharski, MD and subtle notions of Japanese cancer researchers. Role of iron in carcinogenesis: cancer as a ferrotoxic disease ((http://www.tutuz.com/?p=2045)). Brazilian researchers, Japanese researchers and Leo R. Zacharski must read schoolbooks ‘Physics’ (Crystallization and Ferromagnetism). Moreover, they must become acquainted with: 1) American cancer research-1905 on “masked” iron within tumor cells ((http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2100013/?page=2)); 2) American cell-ferromagnetic research-1987 ((http://www.tutuz.com/?p=1161)), ((http://www.cell.com/biophysj/abstract/S0006-3495(87)83243-5)) [body tissues are not ferromagnetic, but ferromagnetic particles can be present as contaminants within living cells]; 3) American cell-ferromagnetic research-1980 and research-1998 ((http://www.tutuz.com/?p=1531)), ((http://jeb.biologists.org/cgi/reprint/92/1/333.pdf)). Brazilian researchers, Japanese researchers and Leo R. Zacharski must admit role of iron in carcinogenesis: cancer as a ferromagnetic disease. Biblical non-complicated anti-iron methods can beat any onco-pathology, ALS, AIDS and Great Money. Holy Writ, Pentagon and Ferromagnetic Theory of Cancer ((http://www.tutuz.com/?p=1698)). Any human cell is society of dia-, para-, ferri- and ferromagnetic nano-objects that have local magnetic contacts. Cancer/tumor viruses (crystalline organisms with DNA/RNA) can provoke crystallization of iron within human cells. Iron overload diseases can provoke crystallization of iron within human cells. Any onco-pathology and Amyotrophic Lateral Sclerosis / Motor Neuron Disease (ALS / MND) ‘work’ by ferromagnetic nano-crystals of iron within human cells. Intracellular ferromagnetic nano-crystals of iron can chaotically distort DNA by local invisible magnetic fields. Intracellular iron metabolism: atoms (ions) of iron, various molecules of heme iron, various molecules of non-heme iron, nano-crystals of iron. Nano-crystals of iron ‘eat’ atoms (ions) of iron. Nano-crystals of iron suppress synthesis of molecules of heme iron and molecules of non-heme iron. That is why German researcher Otto H. Warburg invented Warburg’s cancer theory. Cancer cells live ‘without’ oxygen; cancer cells are anaerobic. Warburg hypothesized that cancer, malignant growth, and tumor growth are caused by the fact that tumor cells mainly generate energy by non-oxidative breakdown of glucose.
Associacao Brasileira de Medicina Biomolecular. Cancer e Excesso de Ferro no Organismo ((http://www.medicinacomplementar.com.br/tema221009e.asp)). Cancer as a ferrotoxic disease. Toyokuni S. Department of Pathology and Biological Responses, Graduate School of Medicine, Nagoya University, Japan. Iron works as a double-edged sword, and its excess is a risk for cancer. Iron and carcinogenesis: from Fenton reaction to target genes. Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Iron, the most abundant transition metal ion in our body, may work as a catalyst for the generation of ROS in pathological conditions. In the past few years, there have been great advances in the understanding of iron metabolism. These include the discoveries of iron transporters and the gene responsible for hereditary hemochromatosis. Iron overload has been shown to be associated with carcinogenesis. The novel concept of 'genomic sites vulnerable to the Fenton reaction'. Here, recent new findings on iron metabolism are reviewed and the concept of the vulnerable sites explored. More effort to link iron metabolism with human carcinogenesis is anticipated. Does excess iron play a role in breast carcinogenesis? An unresolved hypothesis. Cancer Causes Control. Kabat GC, Rohan TE. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, USA. Free iron is a pro-oxidant and can induce oxidative stress and DNA damage. Over time a high intake of iron can lead to iron overload. Furthermore, body iron stores increase in women following menopause. Reactive oxygen species produced by normal aerobic cellular metabolism can lead to the release of free iron from ferritin. In the presence of superoxide radical and hydrogen peroxide, stored ferric iron (Fe(3+)) is reduced to ferrous iron (Fe(2+)), which catalyzes the formation of the hydroxyl radical (*OH). *OH in turn can promote lipid peroxidation, mutagenesis, DNA strand breaks, oncogene activation, and tumor suppressor inhibition, increasing the risk of breast cancer. Mechanisms of disease: The role of hepcidin in iron homeostasis--implications for hemochromatosis and other disorders. Pietrangelo A, Trautwein C. Center for Hemochromatosis and Hereditary Liver Disease, University Hospital of Modena, Italy. The modulation of hepcidin activity using agonists or antagonists might offer new treatment opportunities in different human iron-dependent disorders.
Risco de cancer gastrointestinal Deficiencia de ferro ((http://www.medicinacomplementar.com.br/tema701210cex.asp)). Saobem conhecidos os trabalhos sobre o excesso de ferro aumentando o risco de varios tipos de cancer incluindo o gastrointestinal. A possible link between iron deficiency and gastrointestinal carcinogenesis. Pra D, Rech Franke SI, Pegas Henriques JA, Fenech M. Nutr. Cancer. Universidade Catolica de Pelotas, Pelotas, RS, Brasil. There is definitive evidence that iron overload induces oxidative stress and DNA damage, which can enhance carcinogenic risk. Based on clinical, epidemiological, and experimental evidence, we discuss how iron deficiency might contribute to increased cancer risk through the impairment of several iron-dependent metabolic functions that are related to genome protection and maintenance.
Decreased Cancer Risk After Iron Reduction in Patients With Peripheral Arterial Disease: Results From a Randomized Trial. Leo R. Zacharski; Bruce K. Chow; Paula S. Howes; Galina Shamayeva; John A. Baron; Ronald L. Dalman; David J. Malenka; C. Keith Ozaki; Philip W. Lavori. Background: Excess iron has been implicated in cancer risk through increased iron-catalyzed free radical-mediated oxidative stress. Iron reduction was associated with lower cancer risk and mortality. Further studies are needed to define the role of body iron in cancer risk ((http://www.ncbi.nlm.nih.gov/pubmed/18612130)).
Leo R. Zacharski, MD, Research Service, White River Junction VA Medical Center, Department of Veterans Affairs Medical Center. Cancer risk after randomization was associated with the ferritin level during follow-up but not with other demographic or randomization variables at baseline, including baseline ferritin level. Findings from this study support the hypothesis that ambient levels of body iron stores represented by the serum ferritin level are associated with cancer risk and that lowering iron levels reduces cancer risk. These data suggest that ambient levels of iron stores may be noxious and constitute a "public" problem that affects large segments of the population. Iron ingested in excess cannot be recognized by our senses as potentially noxious. Iron stores rise slowly with aging to levels that are not obviously related temporally to disease that appears capriciously, for no obvious reason. The term "ferrotoxic disease" is useful to distinguish these diseases from acute iron toxicity and the classic iron overload disorder, hereditary hemochromatosis. Iron deficiency may exist when ferritin levels decline to less than about 12 ng/mL, whereas ferrotoxic disease may occur with levels greater than about 50 ng/mL. However, threshold levels of body iron capable of contributing to disease risk may vary according to the disease in question, the antioxidant status of the individual, and other factors. Patterns of iron increase over time may account for differences in disease risk according to age and sex and also in blacks, whose levels of body iron exceed those of whites. The administration of iron to iron-replete cancer patients with anemia should be evaluated for possible adverse effects on cancer outcomes. It is conceivable that phlebotomy may reduce cancer risk by a mechanism independent of iron reduction. Nonetheless, our data exhibit statistical strength and mechanistic plausibility and coincide with previous data on reduced cancer risk with lower body iron stores in premenopausal women, blood donors, and phlebotomized patients with hepatitis C. Further studies of the relationship between levels of body iron and cancer outcomes are needed ((http://www.medscape.com/viewarticle/578562_4)).
Otto H. Warburg invented Warburg’s cancer theory. Leo R. Zacharski, Brazilian researchers and Japanese researchers can invent ferrotoxic cancer theory. Ferromagnetic Cancer Theory will eat ferrotoxic cancer theory soon.
Tigran H. & V. Shapoval http://www.tutuz.com/ South Carolina, USA
Nucleation and Crystal Growth Theories, Theory of Ferromagnetism and Ferromagnetic Theory of Cancer ((http://www.tutuz.com/?p=2079))
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Wiley Online Library http://www.96147.com/no/onlinelibrary.wiley.com%20%2B%20password:.html
