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The Italian chemist Sobrero first synthesized nitroglycerin in 1846 by combining nitric and sulphuric acids with glycerin. Nitroglycerin's possible value as a therapeutic agent was first investigated by Constantin Hering, a homeopathic physician. Born in Germany in 1800, Hering studied medicine at the Universities of Leipzig and Wurzburg and received his medical degree in 1826. Ironically, he was converted to homeopathy when he read Samuel Hahnemann's writings while preparing a refutation of homeopathy. After emigrating to America, Hering settled in Philadelphia and became "the most powerful factor in the growth of early American homeopathy." Hering asked the Philadelphia chemist Morris Davis to synthesize nitroglycerin and collaborated with several homeopathic physicians in a series of self-experiments with the substance in the late 1840s.

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A thorough review of the standard homeopathic texts of the middle of the 19th century has failed to reveal any suggestion that the agent be used for angina pectoris, however. Although angina was an uncommon complaint, numerous remedies for it were included in the homeopathic pharmacopeia.

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