Exposures to oxidizing, electrophilic, acidic, or basic gases frequently happen in occupational and ambient environments. Corrosive gases and vapors such as chlorine, phosgene, and chloropicrin have been used as warfare brokers and in terrorist acts. Chemical airway exposures are detected by the olfactory, gustatory, and nociceptive sensory techniques that provoke protective physiological and behavioral responses. This evaluate focuses on the function of airway nociceptive sensory neurons in chemical sensing and discusses the latest discovery of neuronal receptors for reactive chemical substances. Chemicals likely activate TRPA1 through covalent protein modification. Animal research using TRPA1 antagonists or TRPA1-poor mice confirmed the position of TRPA1 in chemically induced respiratory reflexes, ache, and irritation in vivo.