The term "set" refers to the psychic, mental, and emotional state of the individual taking the drug. It includes expectations, intelligence, personality, imagination, mood, and so on. "Setting" refers to the social and physical environment within which drug use takes place. It could refer to the user's immediate surroundings, such as a living room in one's own house, or it could refer to the broader social and cultural scene—for instance, the legal climate of a country with respect to drug use and possession, or the degree of condemnation of use and users.

Setting involves such matters as whether one takes a drug with friends or with strangers, in surroundings that one is comfortable or uncomfortable with, while engaged in activities that are compatible with or clash with the drug state—such as driving or interacting with strangers. Clearly, setting in part determines set..

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