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One instance is pH-release mesalamine (Asacol®; Procter & Gamble Pharmaceuticals, Cincinnati, OH, USA), which utilizes a gastro-resistant resin film (eg, Eudragrit-S®) that dissolves at a pH of seven or greater, releasing the energetic mesalamine.
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A pricing system has been launched which signifies that the HSE will set one value, referred to as the reference price, that it'll pay for a group of interchangeable medicines Reference Pricing is being launched one medicine at a time, so not all people, or all medicines, will probably be affected without delay.
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However, dibutyl phthalate (DBP) is an inactive ingredient in Asacol's enteric coating, and in animal studies in rats at doses larger than one hundred ninety occasions the human dose based mostly on physique surface space, maternal DBP was associated with external and skeletal malformations and opposed effects on the male reproductive system Asacol must be used throughout being pregnant only if the potential benefit justifies the potential danger to the fetus.
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