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This therapeutic approach uses the mixture of a luteinizing hormone-releasing hormone analogue (LHRH-A) reminiscent of ZOLADEX with an antiandrogen comparable to CASODEX to obtain most suppression of testosterone, the male hormone that can stimulate growth of cancerous cells within the prostate gland.
LUPRON DEPOT three.seventy five mg plus norethindrone acetate treatment ought to be discontinued if there is a sudden partial or complete loss of vision or if there may be sudden onset of proptosis, diplopia, or migraine. Additional, a greater proportion of patients on the enzalutamide arm achieved a PSA response of at the least 50% (81% vs. 31%; P <001).
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Radiographic development-free survival was defined because the time from randomization to the first objective proof of radiographic illness progression or demise on research (death because of any trigger as much as and including 30 days after treatment discontinuation), whichever occurred first.
Your remedy with CASODEX ought to start concurrently your remedy with the LHRH medication. For safe and efficient use of norethindrone acetate with LUPRON DEPOT 11.25 mg, consult with the norethindrone prescribing information. A patient could receive up to 3 month-to-month injections of LUPRON DEPOT three.seventy five mg. Alternatively, casodex alternatives of LUPRON DEPOT eleven.25 mg could also be used only if your physician decides three months of hormonal suppression is important.
Since casodex over the counter united states might lengthen the QT interval, the concomitant use of bicalutamide with medicinal products recognized to delay the QT interval or medicinal products capable of induce Torsade de pointes comparable to class IA (e.g. quinidine, disopyramide) or class III (e.g. amiodarone, sotalol, dofetilide, ibutilide), antiarrhythmic medicinal merchandise, methadone, moxifloxacin, antipyschotics, and many others.
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