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LONDON (dpa-AFX) - AstraZeneca (AZN, AZN.L) announced Friday that it has sold the industrial rights to Arimidex (anastrozole) and Casodex (bicalutamide) in quite a lot of European, African and different countries to Juvisé Prescription drugs. Generic drugs in an LCA category are listed as full advantages. BICALUTAMIDE (bye ka BATHROOM ta mide) blocks the effect of the male hormone testosterone on the prostate. Frequency has been decided from the incidence of reported adversarial events of hepatic failure in patients receiving therapy in the open-label Casodex arm of the a hundred and fifty mg EPC studies.
Total, enzalutamide lowered the chance for development or death seventy six% (HR = 0.24; 95% CI, zero.18-0.32) compared with bicalutamide. This treatment works by blocking the motion of male hormones within the prostate, slowing development of the medicine should not be used in girls or youngsters.
Speak with your doctor when you really feel fatigued whereas taking Casodex. In the bicalutamide-managed research of chemotherapy-naïve mCRPC sufferers, Grade 3-4 antagonistic reactions have been reported in 39% of XTANDI sufferers and 38% of bicalutamide sufferers.
The most typical unwanted side effects of bicalutamide include sizzling flashes , swelling or ache of the breasts, pain on the whole, fatigue, infection, nausea, constipation, swelling of the limbs, diarrhea, anemia, elevated urinary frequency , especially at evening, and blood within the urine.
Prothrombin instances should be carefully monitored in sufferers already receiving coumarin anticoagulants who're began on bicalutamide and adjustment of the anticoagulant dose could also be vital. Bicalutamide is used together with a luteinizing hormone releasing hormone (LHRH) analog (eg, goserelin or leuprolide) to deal with stage D2 metastatic prostate most cancers (most cancers that has spread) in males.
Since androgen deprivation remedy could delay the QT interval, the concomitant use of bicalutamide with medicinal products known to lengthen the QT interval or medicinal merchandise in a position to induce Torsade de pointes reminiscent of class IA (e.g. quinidine, disopyramide) or class III (e.g. amiodarone, sotalol, dofetilide, ibutilide), antiarrhythmic medicinal products, methadone, moxifloxacin, antipyschotics, and so forth.
Nevertheless, secure AR overexpression in prostate cancer cells could have distinct results on coactivators and corepressors that may account for bicalutamide agonist activity, significantly if this activity is barely modest relative to a physiologic agonist.
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These medicines should solely be used in locally superior disease in patients at excessive risk of disease development. AstraZeneca still generates a number of hundred million dollars in sales from Casodex, and that revenue may be shifting to J&J and Medivation.