A 52-week feeding study of genetically modified soybeans in F344 rats

(Изучение 52-недельного кормления крыс линии F344 генетически модифицированной соей)

Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health: 3-24-1 Hyakunin-cho, Shinjuku-ku, Tokyo 169-0073, Japan.

A chronic feeding study to evaluate the safety of the genetically modified glyphosate-tolerant soybeans (GM soybeans) was conducted using rats. F344 DuCrj rats were fed diet containing GM soybeans or Non-GM soybeans at the concentration of 30% in basal diet. Non-GM soybeans were closely related strain of GM soybeans. These two diets were adjusted to an identical nutrient level. In this study, the influence of GM soybeans on rats was compared with that of the Non-GM soybeans, and furthermore, to assess the effect of soybeans themselves, the groups of rats fed GM and Non-GM soybeans were compared with a group fed commercial diet (CE-2). General conditions were observed daily and body weight and food consumption were recorded. At the intermediate examination (26 weeks), and at the termination (52 weeks), animals were subjected to hematology, serum biochemistry, and pathological examination. There were several differences in animal growth, food intake, serum biochemical parameters and histological findings between the rats fed the GM and/or Non-GM soybeans and the rats fed CE-2. However, body weight and food intake were similar for the rats fed the GM and Non-GM soybeans. Gross necropsy findings, hematological and serum biochemical parameters, organ weights, and pathological findings showed no meaningful difference between rats fed the GM and Non-GM soybeans. These results indicate that long-term intake of GM soybeans at the level of 30% in diet has no apparent adverse effect in rats.

Крысы линии F344 DuCrj в течение 52 недель употребляли рацион, содержащий 30% трансгенной сои, устойчивой к действию гербицида глифосат. Контрольные группы крыс употребляли 30% не-ГМ сои в дополнение к основному рациону. Использовались родственные сорта ГМ и не-ГМ сои, а общий состав нутриентов в опытной и контрольной группах был идентичен. Все животные проходили ежедневный контроль с регистрацией веса тела и количества потребляемой пищи. На 26 и 52 неделях также проводили гематологические, биохимические и патологические исследования. Вес тела и количество потребляемой пищи оказались идентичными для групп животных, потреблявших ГМ и не-ГМ сою на всем протяжении эксперимента. Гематологические, биохимические и патоморфологические исследования также не обнаружили никаких существенных различий между этими двумя группами. Вывод: хроническое употребление сои, устойчивой к глифосату, в количестве 30% от базовой диеты не приводит к явным негативным последствиям для организма крысы.

PMID: 17657996
Сама статья: A 52-week feeding study of genetically modified soybeans in F344 rats.

A 104-week feeding study of genetically modified soybeans in F344 rats

(Изучение 104-недельного кормления крыс линии F344 генетически модифицированной соей)

Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health. Tokyo, Japan.

A chronic feeding study to evaluate the safety of genetically modified glyphosate-tolerant soybeans (GM soybeans) was conducted using F344 DuCrj rats. The rats were fed diet containing GM soybeans or Non-GM soybeans at the concentration of 30% in basal diet. Non-GM soybeans were a closely related strain to the GM soybeans. These two diets were adjusted to an identical nutrient level. In this study, the influence of GM soybeans in rats was compared with that of the Non-GM soybeans, and furthermore, to assess the effect of soybeans themselves, the groups of rats fed GM and Non-GM soybeans were compared with a group fed commercial diet (CE-2). General conditions were observed daily and body weight and food consumption were recorded. At the termination (104 weeks), animals were subjected to hematology, serum biochemistry, and pathological examinations. There were several differences in animal growth, food intake, organ weights and histological findings between the rats fed the GM and/or Non-GM soybeans and the rats fed CE-2. However, body weight and food intake were similar for the rats fed the GM and Non-GM soybeans. Gross necropsy findings, hematological and serum biochemical parameters, and organ weights showed no meaningful difference between rats fed the GM and Non-GM soybeans. In pathological observation, there was neither an increase in incidence nor any specific type of nonneoplastic or neoplastic lesions in the GM soybeans group in each sex. These results indicate that long-term intake of GM soybeans at the level of 30% in diet has no apparent adverse effect in rats.

При увеличении продолжительности питания в два раза отрицательных последствий от генетически модифицированной сои обнаружено не было.

PMID: 18787312
Сама статья: A 104-week feeding study of genetically modified soybeans in F344 rats

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