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31  CDF, - ,   «  -   1,96 ».   ,   , ... . , , ,   , , . ,   , , .  , . , «» ,     . « » — ,   .

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CDF Collaboration. Study of multi-muon events produced in p-pbar collisions at sqrt(s)=1.96 TeV // arXiv:0810.5357 (29 October 2008).



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, 2 - . () - , . Physical Review Letters.

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SAR and SAR paradox

, 19 2008 . 11:52 +
The basic assumption for all molecule based hypotheses is that similar molecules have similar activities. This principle is also called Structure-Activity Relationship (SAR). The underlying problem is therefore how to define a small difference on a molecular level, since each kind of activity, e.g. reaction ability, biotransformation ability, solubility, target activity, and so on, might depend on another difference. A good example was given in the bioisosterism review of Patanie/LaVoie.
In general, one is more interested in finding strong trends. Created hypotheses usually rely on a finite number of chemical data. Thus, the induction principle should be respected to avoid overfitted hypotheses and deriving overfitted and useless interpretations on structural/molecular data.
The SAR paradox refers to the fact that it is not the case that all similar molecules have similar activities.


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