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Eat Chocolate and Enjoy Better Sex

Понедельник, 23 Сентября 2019 г. 01:20 + в цитатник

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There are distinct differences between the three clinically approved PDE5 inhibitors, sildenafil, vardenafil, and tadalafil, regarding their selectivity and specificity for PDE inhibition, with consequences on safety profile but also on biopharmaceutic and pharmacokinetic disparities that largely affect efficacy of the compounds (Klotz et al., 2001; Gresser and Gleiter, 2002; Milligan et al., 2002; Muirhead et al., 2002; Nichols et al., 2002; Burgess et al., 2008). Sildenafil and vardenafil are very similar in terms of chemical structure, whereas tadalafil, with a methyldione structure, differs markedly (Figure 2). These chemical properties are also reflected in similarities and dissimilarities of their clinical pharmacokinetics.
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(e) Red phosphorus.
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Along with the previously reported comparison suggesting no benefit to dapagliflozin between patients with and without type 2 diabetes, a post-hoc subgroup analysis showed similar benefit whether patients were on an angiotensin receptor-neprilysin inhibitor (ARNI) at baseline or not -- HR 0.75, 95% CI 0.50-1.13 and HR 0.74, 95% CI 0.65-0.86, respectively.
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Flaherty JH, Perry HM, Lynchard GS, Morley JE. Polypharmacy and hospitalization among older home care patients. J Gerontol A Biol Sci Med Sci. 2000;55(10):M554–9.
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