Python 2 reaches EOL on 2020-01-01 and one of its commonly used third-party packages is MySQL-python. If you have not yet migrated away from both of these, since MySQL-python does not support Python 3, then you may have come across some issues if you are using more recent versions of MySQL and are enforcing a [&]

https://www.percona.com/blog/2019/04/18/mysql-python-adding-caching_sha2_password-tlsv1-2-support/