With the exception of the three configuration variables described here, ProxySQL will only parse the configuration files the first time it is started, or if the proxysql.db file is missing for some other reason. If we want to change any of this data we need to do so via ProxySQLs admin interface and then save them [&]

https://www.percona.com/blog/2018/10/11/how-to-fix-proxysql-configuration-when-it-wont-start/